How will benzodiazepines impact Vibrant's Neurotransmitter test results?

Benzodiazepines act on the GABA receptor to increase GABA transmission. Long-term use of benzodiazepines can lead to down-regulation of the GABA receptors. According to available literature, it does not appear that benzodiazepines affect GABA levels or GABA metabolism. Since benzodiazepines are physically addictive and the withdrawal process is complex, Vibrant does not advise discontinuing this medication for the purposes of testing unless the Vibrant ordering provider has experience and specific reasons for doing so. A reasonable amount of time should occur between discontinuing the medication and testing to allow for restoration of homeostasis. Again, only under supervision of a trained prescriber. If the patient is only occasionally taking a benzodiazepine, and is not physically dependent, then it might be prudent to abstain for several days prior to testing to get a baseline. Given the increase in GABA transmission and the potential for decreased GABA receptors in patients on benzodiazepines, one could hypothesize that the body might increase or decrease the production of GABA as a compensatory response to short or long-term use of benzodiazepines. When interpreting NT test results, consider the patient's symptom picture, laboratory findings, and history including medications and supplements. Treatment is directed at the totality of these factors.