Yes. High-dose (10,000 times RDI) biotin supplementation impacts the biotin-streptavidin chemistry of thyroid immunoassays. In the study Effect of High-dose Biotin on Thyroid Function Tests: Case Report and Literature Review, a patient’s TSH appeared low and free T4 appeared high while on biotin, but normal when off biotin. Visit https://pubmed.ncbi.nlm.nih.gov/30140596/ and view Table 1 to see how much biotin supplementation impacted the test.
Will biotin supplementation impact thyroid results?
Adair
