What could high Total IgA indicate?

IgA protects against infections of the mucous membranes. Therefore, IgA is present in the mouth, digestive tract, respiratory tract (including bronchial secretions) and urogenital tract. It is also found in saliva, tears, and breast milk. High levels of Total IgA are associated with some autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE) as well as liver diseases like cirrhosis and long-term (chronic) hepatitis. High Total IgA may mean that IgA monoclonal gammopathy of unknown significance (MGUS) or IgA multiple myeloma is present. High Total IgA may cause false positives for specific IgA antibody test results (Food Zoomers, Neural Zoomer, Tickborne).

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