To explore root causes of histamine intolerance, consider testing:
- Food Allergens can help gain insight into current IgE reactive foods & environmental allergies.
- Total IgE, if elevated, may be indicative of parasitic infections which can play a role in immune activation and histamine intolerance.
- Gut Zoomer can provide insight into how the gut microbiome is impacting the immune system. Additionally, some research suggests that a greater abundance of histamine-secreting bacteria in the gut could lead to the development of histamine intolerance.
- Environmental Toxins are often implicated in MCAS.
- Mycotoxins are often implicated in MCAS.
- Total Toxic Burden can provide insight into total toxic body burden which could trigger the body's mast cells to release histamine.
- Wheat Zoomer to investigate intestinal permeability and to examine gluten sensitivity. One hypothesis is that people with non-celiac gluten sensitivity have lower levels of the enzyme diamine oxidase which degrades histamine.
- Food Sensitivity IgA/IgG/IgG4/C3D-- if increased intestinal permeability is present, multiple food sensitivities is likely and may trigger downstream histamine response in sensitive individuals. Food Sensitivity testing can inform a personalized anti-inflammatory diet (i.e. eating only the lowest reactive foods), which can reduce inflammation, oxidative stress, and symptoms.
- Neurotransmitters test includes urinary histamine levels. A small portion of the histamine that circulates through the kidney is excreted intact. Thus, the measurement of urinary histamine may be utilized to monitor fluctuations in plasma histamine and has several advantages: stability, accessibility, and the opportunity for retrospective analysis.
