Mean platelet volume (MPV) may be low due to the following:
- Primary or secondary thrombocytosis
- Aplastic anemia
- Autoimmune diseases (e.g., Idiopathic thrombocytopenic purpura, lupus)
- Side effects from medications that impact coagulation (e.g., oral contraceptives)
- Bacterial or viral infections
- Inherited platelet disorders: https://ashpublications.org/hematology/article/2005/1/396/19269/Inherited-Platelet-Disorders
To test for inherited platelet disorders, Vibrant offers Factor II & Factor V Leiden
There are also certain conditions that may influence MPV results:
- Altitude
- Pregnancy
- Menstruation
- Regular (excessively) strenuous exercise
