What could low Total IgA indicate?

Some people are born with low or absent levels of IgA. Low levels occur in some types of leukemia, kidney damage (nephrotic syndrome), a problem with the intestines (enteropathy), and a rare inherited disease that affects muscle coordination (ataxia-telangiectasia). This increases the chances of developing an autoimmune disease. Patients with low IgA are at some increased risk of developing severe reactions after receiving blood products.