Can beta-glucuronidase be high in females and males without hormone imbalance or disorders?

It is important to recognize that the microbiota disease associations are risk-related, based on the relative abundance of the bacterial genus and species tested, and the associated disease risks are not diagnostic of hormone imbalance.

A person may have dysbiosis in the bacterial genera (and their related species within the genus) that leads to elevated beta-glucuronidase independent of their current serum, saliva, or urinary hormones.  

Over time chronic microbiota dysbiosis may increase the risk of developing hormone-related disorders. Thus individuals and practitioners may wish to biomonitor the microbiota and hormones serially over time. 

Beta Glucuronidase- Bacterial Genera That Encode Beta-Glucuronidase

Bacteroides
Bifidobacterium
Citrobacter
Clostridium
Dermabacter
Escherichia
Faecalibacterium
Lactobacillus
Marvinbryantia
Propionibacterium
Roseburia
Tannerella

 

Reference

Kwa, M., Plottel, C. S., Blaser, M. J., & Adams, S. (2016). The intestinal microbiome and estrogen receptor-positive female breast cancer. Journal of the National Cancer Institute108(8), djw029. https://doi.org/10.1093/jnci/djw029

 

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