For most "wellness" and "screening" tests, unless testing specifically for viral, bacterial, fungal, or parasitic infections, it is desirable to test in a "normative" state- when the person is feeling "normal" for their “baseline” health and functioning, and when they are eating their typical diet and engaging in their typical lifestyle and activities of daily living.
The immune system interacts with several other body systems to maintain overall health and respond to various challenges, including infection. The immune system maintains bidirectional signaling with the following body systems:
- Nervous System: The immune system communicates with the nervous system through the release of signaling molecules, such as cytokines. The nervous system, in turn, can influence immune responses through the autonomic nervous system.
- Endocrine System: Hormones released by the endocrine system, such as cortisol from the adrenal glands, can modulate immune function. The immune system, through cytokines, can also influence the endocrine system.
- Circulatory System: The circulatory system, including the blood and lymphatic systems, plays a crucial role in transporting immune cells, antibodies, and other immune components throughout the body to sites of infection or injury.
- Respiratory System: The respiratory system is a common entry point for pathogens. The immune system in the respiratory mucosa helps prevent infections, and immune responses may be triggered in response to respiratory infections.
- Digestive System: The immune system in the digestive tract helps protect against pathogens and supports the absorption of nutrients. The gut-associated lymphoid tissue (GALT) is a significant component of the immune system in the digestive system.
- Integumentary System: The skin, as part of the integumentary system, serves as a physical barrier against pathogens. The immune system in the skin helps prevent infections and responds to injuries. Lymphatic System: The lymphatic system is closely associated with the immune system. Lymph nodes, spleen, and other lymphoid organs are important components where immune cells are produced, matured, and activated.
- Urinary System: The immune system helps protect the urinary tract from infections. Immune responses may be triggered in response to urinary tract infections.
Overall, unless testing specifically for viral, bacterial, fungal, or parasitic infections, a person should wait until they recover from infection and return to their normal “baseline” before testing.
