What tests are recommend for patients with suspected with long COVID?

To detect and manage long COVID, various laboratory tests may be recommended, depending on the symptoms and clinical judgment of the healthcare provider. Long COVID, also known as Post-Acute Sequelae of SARS-CoV-2 infection (PASC), can present with a wide range of symptoms affecting multiple organ systems, and there is no single diagnostic test for it. However, the following tests may be considered to evaluate organ function and to rule out other conditions:

  • Complete Blood Count (CBC): To check for signs of anemia, infection, and other hematological abnormalities.
  • Comprehensive Metabolic Panel (CMP): This includes tests for liver and kidney function, electrolyte and fluid balance, and blood sugar levels.
  • Fibrinogen and Factor II-V: To check for blood clotting problems, which can be a complication of COVID-19.
  • Inflammation Panel (PLAC, Homocysteine, ox-LDL, MPO, hs-CRP) and Erythrocyte Sedimentation Rate (ESR): These are markers of inflammation that may be elevated in some patients with long COVID.
  • Oxidative Stress Profile: Since long COVID is associated with increased oxidative stress.
  • Cardiac Health Panel: Especially if there are symptoms suggestive of cardiac involvement like chest pain or palpitations.
  • Connective Tissue Disorders: Since COVID-19 can trigger autoimmune responses.
  • Neural Zoom Plus: As long COVID can be associated with increased bloodbrain barrier permeability, neuroinflammation, and neural autoimmunity.

It's important to note that the approach to testing should be individualized, based on the specific symptoms and medical history of the patient. Additionally, research is ongoing, and new findings may lead to changes in the recommended testing protocols

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