Vibrant's Candida + IBS panel results indicating antibodies to cytolethal distending toxin B (CdtB) but no antibodies to vinculin suggest a potentially recent case of gastroenteritis which led to irritable bowel syndrome (IBS). In other words, the immune system responded to the CdtB (a bacterial toxin), but not vinculin (a human protein). A lack of antibodies to vinculin (a body protein) indicate that autoimmunity is not present. The anti-CdtB levels could either remain elevated and lead to anti-vinculin autoimmunity or return to normal. While antibodies to vinculin are more common within 12 months after a bout of food-borne illness, they can appear 12 to 24 months post-infection.
What does it mean if I have antibodies to anti-cytolethal distending toxin B (CdtB) but not anti-vinculin?
Adair