- If both are positive, it suggests a dual problem:
- Autoimmune component (anti-vinculin): long-term motility impairment or neuropathy of the gut.
- Microbial component (Candida): secondary colonization/inflammation due to stasis and barrier dysfunction.
- Together, this pattern suggests:
- Candida is not just incidental but taking advantage of impaired motility.
- Simply eradicating Candida may be insufficient unless motility and autoimmune processes are also addressed.
- Clinically, this combination points to the importance of:
- Motility agents / prokinetics (ginger, Iberogast, low-dose naltrexone, or pharmaceuticals if tolerated).
- Immune modulation (diet, reducing triggers, possibly addressing autoimmunity).
- Targeted antifungal support (food-based + supplement strategies).
What is the significance when anti-vinculin is high plus there is Candida colonization?
Clinical Education Team